Rakesh Karmacharya, M.D., Ph.D.
Dr. Rakesh Karmacharya is an Assistant Professor in Psychiatry at Harvard Medical School and the Director of Stem Cell Research of the MGH Psychiatry Center for Experimental Drugs and Diagnostics. He is also a Physician-Scientist in the Chemical Biology Program at the Broad Institute of Harvard and MIT, and the Medical Director of the Schizophrenia and Bipolar Disorder Research Clinic at McLean Hospital.
Dr. Karmacharya received an A.B. in Biochemical Sciences from Harvard University, an M.S. in Molecular Biophysics from Yale University and an MD and a PhD in Biophysics from the Albert Einstein College of Medicine in New York. His graduate studies focused on theoretical studies of the quantum mechanics of proton tunneling in condensed phase. He completed an internship in Medicine at Massachusetts General Hospital (MGH), and a residency in psychiatry at MGH and McLean Hospital. He served as the Chief Resident of the Schizophrenia and Bipolar Disorder Program. After his residency, he undertook postdoctoral studies under the mentorship of Prof. Stuart L. Schreiber.
Dr. Karmacharya and his team are applying chemical biology approaches to identify "disease signatures" for schizophrenia and bipolar disorder, using neuronal cells generated from induced pluripotent stem cells (iPSCs). The goal is to find reliable and robust cellular features that segregate with disease than can serve as disease signatures. The identification of disease signatures will enable screens of small molecule libraries to delineate molecular targets that modulate these disease signatures and identify new diagnostic and therapeutic leads for schizophrenia and bipolar disorder.